Can I Take These?

Can You Take Folate / Folic Acid and Sertraline Together?

No documented interaction was identified between folate and sertraline in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Folate / Folic Acid page and Sertraline page for other reviewed interactions and reference information.

What the interaction means

Folate's NIH ODS fact sheets name five interacting medications -- methotrexate, phenytoin, carbamazepine, valproate, and sulfasalazine -- and sertraline or SSRIs are not among them. Sertraline's FDA label does not mention folate or folic acid.

No documented interaction between Folate / Folic Acid and Sertraline was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Folate's NIH ODS fact sheets and sertraline's FDA label were checked directly, full text, in both directions. Folate's own named interacting medications do not include SSRIs or other antidepressants.

What the sources say

Folate — Consumer — NIH Office of Dietary SupplementsSertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of Medicine

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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