Can I Take These?

Can You Take Folate / Folic Acid and St. John's Wort Together?

No documented interaction was identified between folate and St. John's Wort in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Folate / Folic Acid page and St. John's Wort page for other reviewed interactions and reference information.

What the interaction means

Folate's NIH ODS fact sheets name five interacting medications -- methotrexate, phenytoin, carbamazepine, valproate, and sulfasalazine -- and St. John's Wort is not among them. NCCIH's St. John's Wort page does not mention folate or folic acid.

No documented interaction between Folate / Folic Acid and St. John's Wort was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Folate's NIH ODS fact sheets and NCCIH's St. John's Wort page were checked directly, full text, in both directions. Folate's own named interacting medications do not include herbal supplements.

What the sources say

Folate — Consumer — NIH Office of Dietary SupplementsSt. John's Wort — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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