Can You Take Folate / Folic Acid and St. John's Wort Together?
No documented interaction was identified between folate and St. John's Wort in the sources reviewed.
See the full Folate / Folic Acid page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
Folate's NIH fact sheets do not mention St. John's Wort. NCCIH's St. John's Wort page does not mention folate or folic acid.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-24
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- St. John's Wort and CiprofloxacinInsufficient evidence
- St. John's Wort and MagnesiumInsufficient evidence
- St. John's Wort and WarfarinUse caution
- St. John's Wort and CalciumInsufficient evidence
- St. John's Wort and IronInsufficient evidence
- St. John's Wort and SertralineUse caution
- St. John's Wort and Vitamin EInsufficient evidence
- St. John's Wort and Vitamin B12Insufficient evidence
- St. John's Wort and Vitamin KInsufficient evidence
- St. John's Wort and LevothyroxineInsufficient evidence
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- St. John's Wort and SpironolactoneInsufficient evidence
- St. John's Wort and AtorvastatinInsufficient evidence
- St. John's Wort and ZincInsufficient evidence
- St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
- St. John's Wort and OmeprazoleInsufficient evidence
- St. John's Wort and MetforminInsufficient evidence
- St. John's Wort and LisinoprilInsufficient evidence
- St. John's Wort and DoxycyclineInsufficient evidence
- St. John's Wort and CopperInsufficient evidence
- St. John's Wort and CaffeineInsufficient evidence
- St. John's Wort and Vitamin DInsufficient evidence
- St. John's Wort and ProbioticsInsufficient evidence
- St. John's Wort and CreatineInsufficient evidence
- St. John's Wort and MelatoninInsufficient evidence
- St. John's Wort and TurmericInsufficient evidence
- St. John's Wort and Vitamin CInsufficient evidence
- St. John's Wort and AshwagandhaInsufficient evidence
- St. John's Wort and Omega-3 / Fish OilInsufficient evidence
- St. John's Wort and LosartanInsufficient evidence
- St. John's Wort and AspirinInsufficient evidence
- St. John's Wort and AmlodipineInsufficient evidence
- St. John's Wort and IbuprofenInsufficient evidence
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