Can You Take Ibuprofen and St. John's Wort Together?
No documented interaction was identified between ibuprofen and St. John's Wort in the sources reviewed.
See the full Ibuprofen page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
Ibuprofen's own FDA label does not name St. John's Wort anywhere in its Drug Interactions section. NCCIH's St. John's Wort page discusses interactions with antidepressants, birth control pills, heart medications, and warfarin, but does not mention ibuprofen or NSAIDs.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-24
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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