Ibuprofen
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) available over-the-counter and by prescription, used to relieve pain, fever, and inflammation.
What it is
Ibuprofen is an NSAID that, per MedlinePlus, 'works by stopping the body's production of a substance that causes pain, fever, and inflammation.' Prescription-strength ibuprofen is used to relieve pain, tenderness, swelling, and stiffness from osteoarthritis and rheumatoid arthritis; nonprescription-strength ibuprofen treats minor aches and pains (headache, muscle aches, arthritis, menstrual periods, the common cold, toothaches, backaches) and reduces fever. Its FDA prescribing information documents drug interactions with ACE-inhibitors (diminished antihypertensive effect), aspirin (reduced ibuprofen protein binding, increased adverse-effect potential), diuretics (reduced natriuretic effect of furosemide and thiazides), lithium (elevated plasma lithium levels), methotrexate (potential enhanced toxicity), and warfarin-type (coumarin) anticoagulants (increased bleeding risk).
Food and timing considerations
Per its FDA label, ibuprofen's drug-interaction guidance does not specify particular timing/spacing between doses of ibuprofen and other medications; interacting drugs listed involve pharmacodynamic or pharmacokinetic effects rather than absorption timing.
Known interaction categories
- Insufficient evidence
- Monitor
- Use caution
- Informational
Published interaction pages on this site
- Ibuprofen and CreatineInsufficient evidence
- Ibuprofen and IronInsufficient evidence
- Ibuprofen and MelatoninInsufficient evidence
- Ibuprofen and LisinoprilMonitor
- Ibuprofen and CiprofloxacinUse caution
- Ibuprofen and CaffeineInsufficient evidence
- Ibuprofen and CopperInsufficient evidence
- Ibuprofen and SertralineUse caution
- Ibuprofen and AtorvastatinInsufficient evidence
- Ibuprofen and CalciumInsufficient evidence
- Ibuprofen and CoQ10 (Coenzyme Q10)Insufficient evidence
- Ibuprofen and DoxycyclineInsufficient evidence
- Ibuprofen and MagnesiumInsufficient evidence
- Ibuprofen and OmeprazoleInsufficient evidence
- Ibuprofen and ProbioticsInsufficient evidence
- Ibuprofen and TurmericInsufficient evidence
- Ibuprofen and Vitamin DInsufficient evidence
- Ibuprofen and PotassiumInsufficient evidence
- Ibuprofen and St. John's WortInsufficient evidence
- Ibuprofen and Vitamin B12Insufficient evidence
- Ibuprofen and Vitamin KInsufficient evidence
- Ibuprofen and ZincInsufficient evidence
- Ibuprofen and SpironolactoneUse caution
- Ibuprofen and LosartanMonitor
- Ibuprofen and WarfarinUse caution
- Ibuprofen and AmlodipineInsufficient evidence
- Ibuprofen and AspirinUse caution
- Ibuprofen and EscitalopramUse caution
- Ibuprofen and Vitamin CInsufficient evidence
- Ibuprofen and MetforminInformational
- Ibuprofen and Omega-3 / Fish OilInsufficient evidence
- Ibuprofen and LevothyroxineInsufficient evidence
- Ibuprofen and AshwagandhaInsufficient evidence
- Ibuprofen and Vitamin EInsufficient evidence
- Ibuprofen and Folate / Folic AcidInsufficient evidence
Related guides
Sources
Last reviewed 2026-08-24
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.