Can I Take These?

Can You Take Ibuprofen and Warfarin Together?

Warfarin's FDA label names ibuprofen by name as a drug that can increase bleeding risk.

Use cautionEvidence: High

See the full Ibuprofen page and Warfarin page for other reviewed interactions and reference information.

What the interaction means

Warfarin's FDA prescribing information lists 'ibuprofen' by name in Table 3, "Drugs that Can Increase the Risk of Bleeding," under "Nonsteroidal Anti-Inflammatory Agents": "celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac." Warfarin's Medication Guide separately instructs patients to tell their doctor before taking NSAIDs. Ibuprofen's own FDA label corroborates: "Because bleeding has been reported when ibuprofen tablets and other NSAIDs have been administered to patients on coumarin-type anticoagulants, the physician should be cautious."

Why it may happen

NSAIDs like ibuprofen inhibit platelet function and can irritate the GI tract, which adds to warfarin's anticoagulant effect on the clotting cascade and increases overall bleeding risk when the two are combined.

Practical context

Because warfarin already carries bleeding-risk warnings and requires close monitoring, anyone on warfarin should talk to the prescriber managing their anticoagulation before starting or regularly using ibuprofen, including OTC use for pain or fever, and watch for unusual bruising or bleeding.

What the sources say

Warfarin Sodium Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of MedicineIbuprofen Tablets, USP — FDA Prescribing Information — Ascend Laboratories, LLC (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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