Can I Take These?

Can You Take Sertraline and Warfarin Together?

Sertraline is named directly on warfarin's FDA label as a drug that can increase bleeding risk.

Use cautionEvidence: High

What the interaction means

Warfarin's FDA prescribing information states in its "Drugs that Increase Bleeding Risk" section: "Examples of drugs known to increase the risk of bleeding are presented in Table 3. Because bleeding risk is increased when these drugs are used concomitantly with warfarin, closely monitor patients receiving any such drug with warfarin." Table 3 lists sertraline by name under "Serotonin Reuptake Inhibitors," alongside other SSRIs/SNRIs (citalopram, escitalopram, fluoxetine, paroxetine, venlafaxine, and others).

Why it may happen

Not further specified by the label beyond classifying sertraline within the serotonin-reuptake-inhibitor drug class named as increasing bleeding risk.

Practical context

Because warfarin already carries a boxed warning for bleeding risk and requires individualized INR-based dose management, the label directs close monitoring during concomitant use rather than avoidance outright. Discuss any new SSRI, including sertraline, with the prescriber managing anticoagulation.

What the sources say

Warfarin Sodium Tablets — FDA Prescribing Information — Amneal Pharmaceuticals LLC (via DailyMed, U.S. National Library of Medicine)Sertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of Medicine

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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