Can I Take These?

Can You Take Metformin and Sertraline Together?

No documented interaction was identified between metformin and sertraline in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Metformin page and Sertraline page for other reviewed interactions and reference information.

What the interaction means

Metformin's FDA label names ~19 drugs/classes affecting glycemic control or lactic-acidosis risk -- sertraline is not among them. Sertraline's FDA label names an extensive drug-interaction list (MAOIs, pimozide, other serotonergic agents, anticoagulants/antiplatelets, CYP2D6 substrates, and more) -- metformin is not among them either.

No documented interaction between Metformin and Sertraline was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Metformin's and sertraline's FDA labels were checked directly, full text, in both directions. Neither drug is named in the other's drug-interaction section.

What the sources say

Sertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of MedicineMetformin Hydrochloride Tablets, USP — FDA Prescribing Information — Granules Pharmaceuticals Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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