Can You Take Creatine and Metformin Together?
No documented interaction was identified between metformin and creatine in the sources reviewed.
See the full Creatine page and Metformin page for other reviewed interactions and reference information.
What the interaction means
Metformin's FDA label names ~19 drugs/classes affecting glycemic control or lactic-acidosis risk (carbonic anhydrase inhibitors, ranolazine, alcohol, diuretics, corticosteroids, and more) -- creatine is not among them. NCCIH's bodybuilding-supplements page (which covers creatine) does not mention metformin.
No documented interaction between Creatine and Metformin was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Metformin's FDA label and NCCIH's bodybuilding-supplements page were checked directly, full text, in both directions. Creatine is not among metformin's named glycemic-control or clearance concerns.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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