Can You Take Creatine and Probiotics Together?
No documented interaction was identified between creatine and probiotics in the sources reviewed.
See the full Creatine page and Probiotics page for other reviewed interactions and reference information.
What the interaction means
NCCIH's probiotics page's only medication-related discussion anywhere is research on reducing antibiotic-associated diarrhea -- it names no other drug and does not mention creatine. NCCIH's bodybuilding-supplements page (which covers creatine) does not mention probiotics.
No documented interaction between Creatine and Probiotics was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
NCCIH's probiotics page and NCCIH's bodybuilding-supplements page were checked directly, full text, in both directions. Creatine is not an antibiotic, so probiotics' one documented medication-related finding does not apply here.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- Probiotics and CalciumInsufficient evidence
- Probiotics and LisinoprilInsufficient evidence
- Probiotics and OmeprazoleInsufficient evidence
- Probiotics and Omega-3 / Fish OilInsufficient evidence
- Probiotics and CopperInsufficient evidence
- Probiotics and ZincInsufficient evidence
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- Probiotics and MetforminInsufficient evidence
- Probiotics and TurmericInsufficient evidence
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- Probiotics and AshwagandhaInsufficient evidence
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- Probiotics and SpironolactoneInsufficient evidence
- Probiotics and LosartanInsufficient evidence
- Probiotics and SertralineInsufficient evidence
- Probiotics and St. John's WortInsufficient evidence
- Probiotics and CoQ10 (Coenzyme Q10)Insufficient evidence
- Probiotics and AmlodipineInsufficient evidence
- Probiotics and IbuprofenInsufficient evidence
- Probiotics and EscitalopramInsufficient evidence
- Probiotics and CaffeineInsufficient evidence
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