Creatine
An amino acid the body produces naturally, also taken as a supplement to support exercise performance.
What it is
Creatine is an amino acid produced by the body and a popular dietary supplement. Research suggests it may somewhat enhance the effects of exercise on strength, muscle mass, and endurance. NCCIH notes possible reports of impaired liver or kidney function and compartment syndrome with creatine use, and that its safety in children and teens hasn't been established.
Known interaction categories
- Insufficient evidence
- Informational
Published interaction pages on this site
- Creatine and CalciumInsufficient evidence
- Creatine and CiprofloxacinInsufficient evidence
- Creatine and IronInsufficient evidence
- Creatine and SpironolactoneInsufficient evidence
- Creatine and MagnesiumInsufficient evidence
- Creatine and CaffeineInformational
- Creatine and Vitamin KInsufficient evidence
- Creatine and LevothyroxineInsufficient evidence
- Creatine and Vitamin B12Insufficient evidence
- Creatine and CoQ10 (Coenzyme Q10)Insufficient evidence
- Creatine and PotassiumInsufficient evidence
- Creatine and TurmericInsufficient evidence
- Creatine and CopperInsufficient evidence
- Creatine and St. John's WortInsufficient evidence
- Creatine and OmeprazoleInsufficient evidence
- Creatine and ZincInsufficient evidence
- Creatine and LisinoprilInsufficient evidence
- Creatine and DoxycyclineInsufficient evidence
- Creatine and MetforminInsufficient evidence
- Creatine and MelatoninInsufficient evidence
- Creatine and ProbioticsInsufficient evidence
- Creatine and WarfarinInsufficient evidence
- Creatine and SertralineInsufficient evidence
- Creatine and AtorvastatinInsufficient evidence
- Creatine and Vitamin DInsufficient evidence
Sources
Last reviewed 2026-08-22
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.