Can You Take Creatine and St. John's Wort Together?
No documented interaction was identified between St. John's Wort and creatine in the sources reviewed.
See the full Creatine page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
NCCIH's St. John's Wort page does not mention creatine. NCCIH's bodybuilding-supplements page (which covers creatine) does not mention St. John's Wort.
No documented interaction between Creatine and St. John's Wort was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both Creatine's and St. John's Wort's own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- St. John's Wort and SertralineUse caution
- St. John's Wort and Vitamin EInsufficient evidence
- St. John's Wort and Vitamin KInsufficient evidence
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- St. John's Wort and SpironolactoneInsufficient evidence
- St. John's Wort and OmeprazoleInsufficient evidence
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- St. John's Wort and DoxycyclineInsufficient evidence
- St. John's Wort and CopperInsufficient evidence
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- St. John's Wort and Vitamin CInsufficient evidence
- St. John's Wort and CalciumInsufficient evidence
- St. John's Wort and IronInsufficient evidence
- St. John's Wort and MagnesiumInsufficient evidence
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- St. John's Wort and AshwagandhaInsufficient evidence
- St. John's Wort and Omega-3 / Fish OilInsufficient evidence
- St. John's Wort and ZincInsufficient evidence
- St. John's Wort and LisinoprilInsufficient evidence
- St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
- St. John's Wort and Folate / Folic AcidInsufficient evidence
- St. John's Wort and AtorvastatinMonitor
- St. John's Wort and LosartanInsufficient evidence
- St. John's Wort and MelatoninInsufficient evidence
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- St. John's Wort and AspirinInsufficient evidence
- St. John's Wort and AmlodipineInsufficient evidence
- St. John's Wort and LevothyroxineInsufficient evidence
- St. John's Wort and IbuprofenInsufficient evidence
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