Can You Take Creatine and St. John's Wort Together?
No documented interaction was identified between St. John's Wort and creatine in the sources reviewed.
What the interaction means
NCCIH's St. John's Wort page does not mention creatine. NCCIH's bodybuilding-supplements page (which covers creatine) does not mention St. John's Wort.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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