Can You Take Amlodipine and St. John's Wort Together?

What the interaction means

Amlodipine's FDA prescribing information does not name St. John's Wort; it states a class-level caution only: "Blood pressure should be closely monitored when amlodipine is co-administered with CYP3A4 inducers," without naming any specific inducer. NCCIH's St. John's Wort fact sheet does not mention amlodipine, calcium channel blockers, or blood pressure medications as a class; its named drug interactions are warfarin, digoxin, ivabradine, antidepressants, birth control pills, cyclosporine, anticonvulsants, certain antiretrovirals, certain cancer drugs, and simvastatin.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

St. John's Wort is well documented elsewhere as a strong inducer of CYP3A4, the same enzyme pathway amlodipine's label flags a general monitoring caution for -- a plausible shared mechanism was checked directly, but neither source names the other, so no interaction is documented in the sources reviewed. This mirrors the same treatment already used elsewhere in this project for an equivalent situation (Losartan + St. John's Wort).

What the sources say

Related interactions

• Amlodipine and CalciumInsufficient evidence
• Amlodipine and MetforminMonitor
• Amlodipine and CaffeineInsufficient evidence
• Amlodipine and CiprofloxacinInsufficient evidence
• Amlodipine and CoQ10 (Coenzyme Q10)Insufficient evidence
• Amlodipine and DoxycyclineInsufficient evidence
• Amlodipine and AtorvastatinInformational
• Amlodipine and CopperInsufficient evidence
• Amlodipine and CreatineInsufficient evidence
• Amlodipine and IronInsufficient evidence
• Amlodipine and LevothyroxineInsufficient evidence
• Amlodipine and MagnesiumInformational
• Amlodipine and PotassiumInsufficient evidence
• Amlodipine and SertralineInsufficient evidence
• Amlodipine and LisinoprilInsufficient evidence
• Amlodipine and MelatoninInsufficient evidence
• Amlodipine and OmeprazoleInsufficient evidence
• Amlodipine and ProbioticsInsufficient evidence
• Amlodipine and SpironolactoneInsufficient evidence
• Amlodipine and TurmericInsufficient evidence
• Amlodipine and Vitamin DInsufficient evidence
• Amlodipine and WarfarinInformational
• Amlodipine and Vitamin B12Insufficient evidence
• Amlodipine and Vitamin KInsufficient evidence
• Amlodipine and ZincInsufficient evidence
• Amlodipine and Vitamin CInsufficient evidence
• Amlodipine and Omega-3 / Fish OilInsufficient evidence
• Amlodipine and LosartanInsufficient evidence
• Amlodipine and AspirinInsufficient evidence
• Amlodipine and IbuprofenInsufficient evidence
• Amlodipine and EscitalopramInsufficient evidence
• Amlodipine and Vitamin EInsufficient evidence
• Amlodipine and AshwagandhaMonitor
• Amlodipine and Folate / Folic AcidInsufficient evidence
• St. John's Wort and CiprofloxacinInsufficient evidence
• St. John's Wort and MagnesiumInsufficient evidence
• St. John's Wort and WarfarinUse caution
• St. John's Wort and CalciumInsufficient evidence
• St. John's Wort and IronInsufficient evidence
• St. John's Wort and SertralineUse caution
• St. John's Wort and Vitamin EInsufficient evidence
• St. John's Wort and Vitamin B12Insufficient evidence
• St. John's Wort and Vitamin KInsufficient evidence
• St. John's Wort and LevothyroxineInsufficient evidence
• St. John's Wort and PotassiumInsufficient evidence
• St. John's Wort and SpironolactoneInsufficient evidence
• St. John's Wort and AtorvastatinInsufficient evidence
• St. John's Wort and ZincInsufficient evidence
• St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
• St. John's Wort and OmeprazoleInsufficient evidence
• St. John's Wort and MetforminInsufficient evidence
• St. John's Wort and LisinoprilInsufficient evidence
• St. John's Wort and DoxycyclineInsufficient evidence
• St. John's Wort and CopperInsufficient evidence
• St. John's Wort and CaffeineInsufficient evidence
• St. John's Wort and Vitamin DInsufficient evidence
• St. John's Wort and ProbioticsInsufficient evidence
• St. John's Wort and CreatineInsufficient evidence
• St. John's Wort and MelatoninInsufficient evidence
• St. John's Wort and TurmericInsufficient evidence
• St. John's Wort and Vitamin CInsufficient evidence
• St. John's Wort and AshwagandhaInsufficient evidence
• St. John's Wort and Omega-3 / Fish OilInsufficient evidence
• St. John's Wort and Folate / Folic AcidInsufficient evidence
• St. John's Wort and LosartanInsufficient evidence
• St. John's Wort and AspirinInsufficient evidence
• St. John's Wort and IbuprofenInsufficient evidence
• St. John's Wort and EscitalopramUse caution