Amlodipine
A prescription dihydropyridine calcium channel blocker used to treat high blood pressure and certain types of chest pain (angina).
What it is
Amlodipine is a dihydropyridine calcium channel blocker (calcium antagonist). Its FDA label states it works by inhibiting "the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle." It is indicated for the treatment of hypertension, and the Norvasc brand label additionally lists coronary artery disease, including chronic stable angina and vasospastic (Prinzmetal's or variant) angina, among its indications. Amlodipine is extensively metabolized by the liver, with a long elimination half-life of about 30 to 50 hours, and steady-state levels are reached after about 7 to 8 days of daily dosing.
How it is commonly taken
The FDA label states the recommended initial adult dose is 5 mg once daily, with a maximum of 10 mg once daily; small, fragile, or elderly patients, or those with hepatic impairment, may be started at 2.5 mg once daily.
Food and timing considerations
The FDA label states that the bioavailability of amlodipine besylate tablets "is not altered by the presence of food," and that a single dose of grapefruit juice co-administered with amlodipine "had no significant effect on the pharmacokinetics of amlodipine."
Known interaction categories
- Insufficient evidence
- Monitor
- Informational
Published interaction pages on this site
- Amlodipine and CalciumInsufficient evidence
- Amlodipine and MetforminMonitor
- Amlodipine and CaffeineInsufficient evidence
- Amlodipine and CiprofloxacinInsufficient evidence
- Amlodipine and CoQ10 (Coenzyme Q10)Insufficient evidence
- Amlodipine and DoxycyclineInsufficient evidence
- Amlodipine and AtorvastatinInformational
- Amlodipine and CopperInsufficient evidence
- Amlodipine and CreatineInsufficient evidence
- Amlodipine and IronInsufficient evidence
- Amlodipine and LevothyroxineInsufficient evidence
- Amlodipine and MagnesiumInformational
- Amlodipine and PotassiumInsufficient evidence
- Amlodipine and SertralineInsufficient evidence
- Amlodipine and LisinoprilInsufficient evidence
- Amlodipine and MelatoninInsufficient evidence
- Amlodipine and OmeprazoleInsufficient evidence
- Amlodipine and ProbioticsInsufficient evidence
- Amlodipine and SpironolactoneInsufficient evidence
- Amlodipine and TurmericInsufficient evidence
- Amlodipine and Vitamin DInsufficient evidence
- Amlodipine and WarfarinInformational
- Amlodipine and St. John's WortInsufficient evidence
- Amlodipine and Vitamin B12Insufficient evidence
- Amlodipine and Vitamin KInsufficient evidence
- Amlodipine and ZincInsufficient evidence
- Amlodipine and Vitamin CInsufficient evidence
- Amlodipine and Omega-3 / Fish OilInsufficient evidence
- Amlodipine and LosartanInsufficient evidence
- Amlodipine and AspirinInsufficient evidence
- Amlodipine and IbuprofenInsufficient evidence
- Amlodipine and EscitalopramInsufficient evidence
- Amlodipine and Vitamin EInsufficient evidence
- Amlodipine and AshwagandhaMonitor
- Amlodipine and Folate / Folic AcidInsufficient evidence
Related guides
Sources
Last reviewed 2026-08-24
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.