Can I Take These?

Can You Take Amlodipine and Spironolactone Together?

No documented interaction was identified between amlodipine and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Amlodipine page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Amlodipine's FDA prescribing information does not mention spironolactone. Spironolactone's FDA prescribing information does not mention amlodipine or calcium channel blockers.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Amlodipine Besylate Tablets, USP — FDA Prescribing Information — New Horizon Rx Group, LLC (Manufactured by Amneal Pharmaceuticals of NY, via DailyMed, U.S. National Library of Medicine)Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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