Can I Take These?

Can You Take Levothyroxine and Spironolactone Together?

No documented interaction was identified between levothyroxine and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Levothyroxine page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA label names 13 drugs/classes (potassium-increasing agents, ACE inhibitors, ARBs, NSAIDs, heparin, lithium, digoxin, cholestyramine, aspirin, and others) -- levothyroxine is not among them. Levothyroxine's own extensive drug-interaction section does not name spironolactone either.

No documented interaction between Levothyroxine and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Spironolactone's and levothyroxine's FDA labels were checked directly, full text, in both directions. Neither drug is named in the other's drug-interaction section.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Levothyroxine Sodium Capsules — FDA Prescribing Information — YARAL Pharma, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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