Can I Take These?

Can You Take CoQ10 (Coenzyme Q10) and Spironolactone Together?

No documented interaction was identified between CoQ10 and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full CoQ10 (Coenzyme Q10) page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA label names 13 drugs/classes (potassium-increasing agents, ACE inhibitors, ARBs, NSAIDs, heparin, lithium, digoxin, cholestyramine, aspirin, and others) -- CoQ10 is not among them. NCCIH's CoQ10 page names exactly three interaction concerns -- warfarin, insulin, and some cancer treatments -- and spironolactone is not among them either.

No documented interaction between CoQ10 (Coenzyme Q10) and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Spironolactone's FDA label and NCCIH's CoQ10 page were checked directly, full text, in both directions. Neither source names the other.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Coenzyme Q10 — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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