Can I Take These?

Can You Take CoQ10 (Coenzyme Q10) and Spironolactone Together?

No documented interaction was identified between CoQ10 and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

What the interaction means

Spironolactone's FDA label's full Drug Interactions section does not mention CoQ10. NCCIH's CoQ10 page does not mention spironolactone.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Coenzyme Q10 — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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