Can I Take These?

Can You Take Escitalopram and Spironolactone Together?

No documented interaction was identified between escitalopram and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Escitalopram page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA label, Section 5.3, states spironolactone itself "can cause hyponatremia, hypomagnesemia, hypocalcemia, hypochloremic alkalosis, and hyperglycemia" as its own adverse effect, but this is not tied to any SSRI or antidepressant interaction in the label, and the words 'escitalopram,' 'citalopram,' 'SSRI,' 'serotonin,' and 'antidepressant' do not appear anywhere in it. Escitalopram's own FDA label does not mention spironolactone.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions. SSRIs are independently associated with a risk of hyponatremia (via SIADH) in the broader medical literature, which could theoretically compound spironolactone's own hyponatremia risk, but neither drug's own FDA label documents this specific combination, so it is not represented here as a sourced finding.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)LEXAPRO (escitalopram) Tablets and Oral Solution — FDA Prescribing Information — Allergan, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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