Can I Take These?

Can You Take Spironolactone and Zinc Together?

No documented interaction was identified between spironolactone and zinc in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Spironolactone page and Zinc page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA label names 13 drugs/classes (potassium-increasing agents, ACE inhibitors, ARBs, NSAIDs, heparin, lithium, digoxin, cholestyramine, aspirin, and others) -- zinc is not among them. Zinc's own NIH fact sheet interactions section names only quinolone antibiotics, tetracycline antibiotics, penicillamine, and thiazide diuretics -- spironolactone (a potassium-sparing diuretic, not a thiazide) is not among them either.

No documented interaction between Spironolactone and Zinc was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Spironolactone's FDA label and zinc's NIH ODS fact sheet were checked directly, full text, in both directions. Neither source names the other.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Zinc — Consumer — NIH Office of Dietary Supplements

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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