Can I Take These?

Can You Take Folate / Folic Acid and Spironolactone Together?

No documented interaction was identified between folate and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Folate / Folic Acid page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Folate's NIH ODS fact sheets name five interacting medications -- methotrexate, phenytoin, carbamazepine, valproate, and sulfasalazine -- and spironolactone is not among them. Spironolactone's FDA label does not mention folate or folic acid.

No documented interaction between Folate / Folic Acid and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Folate's NIH ODS fact sheets and spironolactone's FDA label were checked directly, full text, in both directions. Folate's own named interacting medications do not include blood pressure medications or diuretics.

What the sources say

Folate — Consumer — NIH Office of Dietary SupplementsSpironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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