Can I Take These?

Can You Take Folate / Folic Acid and Spironolactone Together?

No documented interaction was identified between folate and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Folate / Folic Acid page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Folate's NIH fact sheets do not mention spironolactone. Spironolactone's FDA label does not mention folate or folic acid.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Folate — Consumer — NIH Office of Dietary SupplementsSpironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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