Can I Take These?

Can You Take Magnesium and Spironolactone Together?

No documented interaction was identified between magnesium and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Magnesium page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA label mentions "magnesium" only as "magnesium stearate" (an inactive tablet excipient) and inside its generic taxonomy dropdown -- not an interaction statement. Magnesium's own NIH fact sheet does not mention spironolactone.

No documented interaction between Magnesium and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions; the inactive-ingredient and taxonomy-list mentions were deliberately not treated as a real interaction claim.

What the sources say

Magnesium — Consumer — NIH Office of Dietary SupplementsSpironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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