Can I Take These?

Can You Take Amlodipine and Magnesium Together?

A magnesium-and-aluminum-hydroxide antacid was directly studied with amlodipine and showed no significant effect on amlodipine's levels.

InformationalEvidence: Moderate

See the full Amlodipine page and Magnesium page for other reviewed interactions and reference information.

What the interaction means

Amlodipine's FDA prescribing information states: "Co-administration of a magnesium and aluminum hydroxide antacid with a single dose of amlodipine besylate tablets had no significant effect on the pharmacokinetics of amlodipine." The Norvasc brand label corroborates this: "Co-administered cimetidine, magnesium- and aluminum hydroxide antacids, sildenafil, and grapefruit juice have no impact on the exposure to amlodipine."

Why it may happen

Not further specified by the label beyond reporting no significant pharmacokinetic effect from the antacid combination product studied.

Practical context

This finding is specific to a magnesium-and-aluminum-hydroxide antacid combination product studied in a PK trial, not to an isolated magnesium supplement -- the NIH Office of Dietary Supplements' own magnesium fact sheet does not separately mention amlodipine. Reflected here as informational (studied, no significant effect on amlodipine) rather than a caution.

What the sources say

Magnesium — Consumer — NIH Office of Dietary SupplementsAmlodipine Besylate Tablets, USP — FDA Prescribing Information — New Horizon Rx Group, LLC (Manufactured by Amneal Pharmaceuticals of NY, via DailyMed, U.S. National Library of Medicine)NORVASC (amlodipine besylate) Tablets — FDA Prescribing Information — Pfizer Laboratories Div Pfizer Inc (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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