Can I Take These?

Can You Take Magnesium and Omeprazole Together?

Omeprazole use can lower magnesium levels -- its FDA label documents this directly and recommends monitoring in some patients.

MonitorEvidence: High

What the interaction means

Omeprazole's FDA prescribing information states: "Hypomagnesemia, symptomatic and asymptomatic, has been reported rarely in patients treated with PPIs for at least three months, in most cases after a year of therapy." The label recommends: "For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), healthcare professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically."

Why it may happen

Not further specified by the label beyond describing hypomagnesemia as a reported effect of PPI therapy.

Practical context

The finding is described as rare and tied to longer-term use (at least three months, most cases after a year), particularly relevant for patients also taking other magnesium-lowering medications such as certain diuretics or digoxin. No spacing interval applies -- this is a monitoring consideration, not a same-day dosing conflict.

What the sources say

Omeprazole Delayed-Release Capsules — FDA Prescribing Information — American Health Packaging (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-22

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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