Can I Take These?

Can You Take Magnesium and Melatonin Together?

No documented interaction was identified between magnesium and melatonin in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Magnesium page and Melatonin page for other reviewed interactions and reference information.

What the interaction means

Magnesium's NIH ODS fact sheet names bisphosphonates, certain antibiotics, diuretics, and acid reflux/peptic ulcer drugs as its documented drug interactions -- melatonin is not among them. NCCIH's melatonin page names exactly two classes needing medical supervision -- epilepsy and blood thinner medications -- and magnesium fits neither.

No documented interaction between Magnesium and Melatonin was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Magnesium's NIH ODS fact sheet and NCCIH's melatonin page were checked directly, full text, in both directions. Neither source names the other.

What the sources say

Magnesium — Consumer — NIH Office of Dietary SupplementsMelatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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