Can You Take Melatonin and Probiotics Together?
No documented interaction was identified between melatonin and probiotics in the sources reviewed.
What the interaction means
NCCIH's melatonin page does not mention probiotics. NCCIH's probiotics page does not mention melatonin.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- Melatonin and CoQ10 (Coenzyme Q10)Insufficient evidence
- Melatonin and OmeprazoleInsufficient evidence
- Melatonin and WarfarinInsufficient evidence
- Melatonin and AtorvastatinInsufficient evidence
- Melatonin and MagnesiumInsufficient evidence
- Melatonin and CalciumInsufficient evidence
- Melatonin and CiprofloxacinInsufficient evidence
- Melatonin and SertralineInsufficient evidence
- Melatonin and IronInsufficient evidence
- Melatonin and Vitamin B12Insufficient evidence
- Melatonin and PotassiumInsufficient evidence
- Melatonin and SpironolactoneInsufficient evidence
- Melatonin and ZincInsufficient evidence
- Melatonin and St. John's WortInsufficient evidence
- Melatonin and CopperInsufficient evidence
- Melatonin and LisinoprilInsufficient evidence
- Melatonin and DoxycyclineInsufficient evidence
- Melatonin and MetforminInsufficient evidence
- Melatonin and CreatineInsufficient evidence
- Melatonin and Vitamin DInsufficient evidence
- Melatonin and CaffeineInsufficient evidence
- Melatonin and TurmericInsufficient evidence
- Melatonin and Vitamin KInsufficient evidence
- Melatonin and LevothyroxineInsufficient evidence
- Probiotics and MagnesiumInsufficient evidence
- Probiotics and DoxycyclineInformational
- Probiotics and CiprofloxacinInsufficient evidence
- Probiotics and IronInsufficient evidence
- Probiotics and CalciumInsufficient evidence
- Probiotics and SertralineInsufficient evidence
- Probiotics and PotassiumInsufficient evidence
- Probiotics and Vitamin B12Insufficient evidence
- Probiotics and St. John's WortInsufficient evidence
- Probiotics and SpironolactoneInsufficient evidence
- Probiotics and LisinoprilInsufficient evidence
- Probiotics and OmeprazoleInsufficient evidence
- Probiotics and CopperInsufficient evidence
- Probiotics and ZincInsufficient evidence
- Probiotics and CoQ10 (Coenzyme Q10)Insufficient evidence
- Probiotics and AtorvastatinInsufficient evidence
- Probiotics and Vitamin DInsufficient evidence
- Probiotics and Vitamin KInsufficient evidence
- Probiotics and WarfarinInsufficient evidence
- Probiotics and CreatineInsufficient evidence
- Probiotics and CaffeineInsufficient evidence
- Probiotics and MetforminInsufficient evidence
- Probiotics and LevothyroxineInsufficient evidence
- Probiotics and TurmericInsufficient evidence