Can I Take These?

Can You Take Aspirin and Probiotics Together?

No documented interaction was identified between aspirin and probiotics in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Aspirin page and Probiotics page for other reviewed interactions and reference information.

What the interaction means

Aspirin's own DURLAZA FDA label lists four named drug-interaction categories (RAS inhibitors, anticoagulants/antiplatelets, anticonvulsants, and methotrexate) -- probiotics are not among them. NCCIH's probiotics page discusses interactions with antibiotics specifically, but does not mention aspirin, NSAIDs, blood thinners, or bleeding risk anywhere.

No documented interaction between Aspirin and Probiotics was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Aspirin's DURLAZA label and NCCIH's probiotics page were checked directly, full text, in both directions. Probiotics is not an antibiotic, so the page's antibiotic-associated-diarrhea research does not apply here.

What the sources say

DURLAZA (Aspirin) Extended-Release Capsules — FDA Prescribing Information — New Haven Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)Probiotics: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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