Can You Take Aspirin and St. John's Wort Together?

What the interaction means

Aspirin's own DURLAZA FDA label does not name St. John's Wort anywhere in its Drug Interactions section. NCCIH's St. John's Wort page discusses interactions with antidepressants, birth control pills, heart medications, and warfarin, but does not mention aspirin.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Related interactions

• Aspirin and SertralineUse caution
• Aspirin and LisinoprilMonitor
• Aspirin and WarfarinUse caution
• Aspirin and LevothyroxineMonitor
• Aspirin and AtorvastatinInsufficient evidence
• Aspirin and SpironolactoneMonitor
• Aspirin and CiprofloxacinInformational
• Aspirin and CaffeineInsufficient evidence
• Aspirin and CalciumInsufficient evidence
• Aspirin and CoQ10 (Coenzyme Q10)Insufficient evidence
• Aspirin and DoxycyclineInsufficient evidence
• Aspirin and MagnesiumInsufficient evidence
• Aspirin and MetforminInsufficient evidence
• Aspirin and PotassiumInsufficient evidence
• Aspirin and Vitamin B12Insufficient evidence
• Aspirin and Vitamin KInsufficient evidence
• Aspirin and CopperInsufficient evidence
• Aspirin and CreatineInsufficient evidence
• Aspirin and IronInsufficient evidence
• Aspirin and MelatoninInsufficient evidence
• Aspirin and OmeprazoleInsufficient evidence
• Aspirin and ProbioticsInsufficient evidence
• Aspirin and TurmericInsufficient evidence
• Aspirin and Vitamin DInsufficient evidence
• Aspirin and ZincInsufficient evidence
• Aspirin and AshwagandhaInsufficient evidence
• Aspirin and LosartanMonitor
• Aspirin and AmlodipineInsufficient evidence
• Aspirin and IbuprofenUse caution
• Aspirin and EscitalopramUse caution
• Aspirin and Vitamin CInsufficient evidence
• Aspirin and Omega-3 / Fish OilInsufficient evidence
• Aspirin and Vitamin EUse caution
• Aspirin and Folate / Folic AcidInsufficient evidence
• St. John's Wort and CiprofloxacinInsufficient evidence
• St. John's Wort and MagnesiumInsufficient evidence
• St. John's Wort and WarfarinUse caution
• St. John's Wort and CalciumInsufficient evidence
• St. John's Wort and IronInsufficient evidence
• St. John's Wort and SertralineUse caution
• St. John's Wort and Vitamin EInsufficient evidence
• St. John's Wort and Vitamin B12Insufficient evidence
• St. John's Wort and Vitamin KInsufficient evidence
• St. John's Wort and LevothyroxineInsufficient evidence
• St. John's Wort and PotassiumInsufficient evidence
• St. John's Wort and SpironolactoneInsufficient evidence
• St. John's Wort and AtorvastatinInsufficient evidence
• St. John's Wort and ZincInsufficient evidence
• St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
• St. John's Wort and OmeprazoleInsufficient evidence
• St. John's Wort and MetforminInsufficient evidence
• St. John's Wort and LisinoprilInsufficient evidence
• St. John's Wort and DoxycyclineInsufficient evidence
• St. John's Wort and CopperInsufficient evidence
• St. John's Wort and CaffeineInsufficient evidence
• St. John's Wort and Vitamin DInsufficient evidence
• St. John's Wort and ProbioticsInsufficient evidence
• St. John's Wort and CreatineInsufficient evidence
• St. John's Wort and MelatoninInsufficient evidence
• St. John's Wort and TurmericInsufficient evidence
• St. John's Wort and Vitamin CInsufficient evidence
• St. John's Wort and AshwagandhaInsufficient evidence
• St. John's Wort and Omega-3 / Fish OilInsufficient evidence
• St. John's Wort and Folate / Folic AcidInsufficient evidence
• St. John's Wort and LosartanInsufficient evidence
• St. John's Wort and AmlodipineInsufficient evidence
• St. John's Wort and IbuprofenInsufficient evidence
• St. John's Wort and EscitalopramUse caution