Can I Take These?

Can You Take Aspirin and Ciprofloxacin Together?

Ciprofloxacin's FDA label names aspirin specifically, but to exclude it from an NSAID-related seizure warning that applies to other NSAIDs.

InformationalEvidence: Moderate

See the full Aspirin page and Ciprofloxacin page for other reviewed interactions and reference information.

What the interaction means

Ciprofloxacin's FDA prescribing information states, in its Drug Interactions precautions: "Non-steroidal anti-inflammatory drugs (but not acetyl salicylic acid) in combination of very high doses of quinolones have been shown to provoke convulsions in pre-clinical studies." This is the only mention of aspirin (acetyl salicylic acid) in the label, and it is a direct, deliberate exclusion.

Why it may happen

Not further specified for aspirin beyond the exclusion; the label attributes the preclinical seizure-provoking effect to other NSAIDs combined with very high doses of quinolone antibiotics, and specifically states this does not apply to acetylsalicylic acid.

Practical context

This is a reassuring, not cautionary, finding: while ciprofloxacin's label warns that other NSAIDs combined with very high quinolone doses showed seizure risk in preclinical studies, aspirin is explicitly named as an exception to that particular warning. It is documented here because aspirin is named directly on the label, consistent with this project's practice of citing exact source wording rather than omitting a real, specific mention.

What the sources say

Ciprofloxacin Tablet — FDA Prescribing Information — Rising Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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