Can I Take These?

Can You Take Aspirin and Omega-3 / Fish Oil Together?

No documented interaction was identified between omega-3 and aspirin in the sources reviewed, though both have independent antiplatelet effects.

No documented interaction identifiedEvidence: Moderate

See the full Aspirin page and Omega-3 / Fish Oil page for other reviewed interactions and reference information.

What the interaction means

Omega-3's NIH ODS Health Professional fact sheet's dedicated 'Interactions with Medications' section names only warfarin and similar anticoagulants as its stated example, noting fish oil "can have antiplatelet effects at high doses, although it appears to be less potent than aspirin" -- a potency comparison, not a stated interaction warning. Aspirin's own FDA prescribing information does not mention omega-3, fish oil, EPA, or DHA anywhere.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Why it may happen

Not established as a documented interaction by either source. Omega-3s can have mild antiplatelet effects at high doses, and aspirin is itself an antiplatelet drug, so an additive effect on bleeding risk is biologically plausible, but neither substance's own primary source states this as a caution for the specific combination.

Practical context

This pair was checked with particular care because of the shared antiplatelet mechanism, per this project's research brief. Omega-3's own comprehensive 37-page Health Professional fact sheet discusses aspirin only as a potency comparison for omega-3's own antiplatelet effect and, separately, as background medication use in rheumatoid arthritis trials -- not as a named interaction risk. Anyone taking regular high-dose aspirin who is considering high-dose omega-3 supplementation (well above typical dietary intake) may still want to mention it to their prescriber given the plausible shared mechanism, even though it is not documented as a specific caution in either primary source reviewed.

What the sources say

DURLAZA (Aspirin) Extended-Release Capsules — FDA Prescribing Information — New Haven Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)Omega-3 Fatty Acids - Health Professional Fact Sheet — NIH Office of Dietary Supplements

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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