Can I Take These?

Can You Take Aspirin and Vitamin E Together?

Vitamin E's own NIH fact sheet connects aspirin use to an observed bleeding-risk finding in high-dose vitamin E users.

Use cautionEvidence: Moderate

See the full Aspirin page and Vitamin E page for other reviewed interactions and reference information.

What the interaction means

Vitamin E's own NIH ODS Health Professional fact sheet, discussing two clinical trials that found increased hemorrhagic stroke risk in high-dose alpha-tocopherol users, states: "Because the majority of physicians in the latter study were also taking aspirin, this finding could indicate that vitamin E has a tendency to cause bleeding." The same fact sheet separately states that large doses of vitamin E taken with "anticoagulant or antiplatelet medications" can increase bleeding risk. Aspirin's own FDA prescribing information does not separately name vitamin E or tocopherol.

Why it may happen

Vitamin E can inhibit platelet aggregation and antagonize vitamin K-dependent clotting factors at high doses; aspirin is itself an antiplatelet drug, so combining the two plausibly adds to bleeding risk, consistent with the epidemiological aspirin co-use observation the fact sheet raises.

Practical context

This is an epidemiological/observational finding from a large physician cohort study, hedged by the fact sheet's own language ("could indicate"), not a controlled interaction trial -- so it is rated evidenceQuality "moderate" rather than "high." It is a real, direct connection drawn by vitamin E's own authoritative source, though. Anyone taking regular aspirin who is considering high-dose vitamin E supplementation should discuss it with their prescriber, particularly at doses above the commonly-cited 400 IU/day threshold used elsewhere in vitamin E's bleeding-risk guidance.

What the sources say

DURLAZA (Aspirin) Extended-Release Capsules — FDA Prescribing Information — New Haven Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)Vitamin E - Health Professional Fact Sheet — NIH Office of Dietary Supplements

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related interactions