Can I Take These?

Can You Take Vitamin E and Vitamin K Together?

MedlinePlus states directly that vitamin E can interfere with how vitamin K works in the body.

MonitorEvidence: Moderate

See the full Vitamin E page and Vitamin K page for other reviewed interactions and reference information.

What the interaction means

MedlinePlus's vitamin K page states, in the same passage discussing blood thinners: "You also need to be careful about taking vitamin E supplements. Vitamin E can interfere with how vitamin K works in your body. Ask your health care provider for recommendations about these vitamins." This is independently corroborated by vitamin E's own NIH ODS fact sheet, which describes the mechanism as inhibition of vitamin K-dependent clotting factor function.

Why it may happen

Vitamin E's ODS fact sheet describes vitamin E as "thought to inhibit the oxidation of reduced vitamin K and interfere with the functions of vitamin K-dependent clotting factors," which is consistent with MedlinePlus's plain-language statement that vitamin E interferes with how vitamin K works.

Practical context

This caution appears in MedlinePlus's vitamin K page specifically in the context of people taking blood thinners; MedlinePlus advises asking a health care provider for recommendations about combining these two vitamins, particularly at supplement doses above what a typical diet provides.

What the sources say

Vitamin E - Health Professional Fact Sheet — NIH Office of Dietary SupplementsVitamin K — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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