Can You Take Spironolactone and Vitamin K Together?
No documented interaction was identified between spironolactone and vitamin K in the sources reviewed.
What the interaction means
Spironolactone's FDA label's only 'vitamin K' hits ('VITAMIN K ANTAGONIST', 'VITAMIN K INHIBITORS') are inside its generic pharmacologic-class taxonomy dropdown, not prose interaction statements. MedlinePlus's vitamin K page does not mention spironolactone.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions; the taxonomy-list mentions were deliberately not treated as a real interaction claim.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
Related interactions
- Spironolactone and IronInsufficient evidence
- Spironolactone and PotassiumAvoid combining
- Spironolactone and CalciumInsufficient evidence
- Spironolactone and CoQ10 (Coenzyme Q10)Insufficient evidence
- Spironolactone and CiprofloxacinInsufficient evidence
- Spironolactone and MagnesiumInsufficient evidence
- Spironolactone and CreatineInsufficient evidence
- Spironolactone and CaffeineInsufficient evidence
- Spironolactone and LevothyroxineInsufficient evidence
- Spironolactone and TurmericInsufficient evidence
- Spironolactone and WarfarinInsufficient evidence
- Spironolactone and St. John's WortInsufficient evidence
- Spironolactone and CopperInsufficient evidence
- Spironolactone and SertralineInsufficient evidence
- Spironolactone and MelatoninInsufficient evidence
- Spironolactone and MetforminInsufficient evidence
- Spironolactone and ProbioticsInsufficient evidence
- Spironolactone and Vitamin DInsufficient evidence
- Spironolactone and ZincInsufficient evidence
- Spironolactone and DoxycyclineInsufficient evidence
- Spironolactone and OmeprazoleInsufficient evidence
- Spironolactone and Vitamin B12Insufficient evidence
- Spironolactone and AtorvastatinInsufficient evidence
- Spironolactone and LisinoprilUse caution
- Vitamin K and LisinoprilInsufficient evidence
- Vitamin K and WarfarinUse caution
- Vitamin K and Vitamin DInsufficient evidence
- Vitamin K and CalciumInsufficient evidence
- Vitamin K and IronInsufficient evidence
- Vitamin K and CiprofloxacinInsufficient evidence
- Vitamin K and CreatineInsufficient evidence
- Vitamin K and St. John's WortInsufficient evidence
- Vitamin K and CaffeineInsufficient evidence
- Vitamin K and CopperInsufficient evidence
- Vitamin K and LevothyroxineInsufficient evidence
- Vitamin K and Vitamin B12Insufficient evidence
- Vitamin K and PotassiumInsufficient evidence
- Vitamin K and TurmericInsufficient evidence
- Vitamin K and ZincInsufficient evidence
- Vitamin K and DoxycyclineInsufficient evidence
- Vitamin K and OmeprazoleInsufficient evidence
- Vitamin K and CoQ10 (Coenzyme Q10)Insufficient evidence
- Vitamin K and MagnesiumInsufficient evidence
- Vitamin K and ProbioticsInsufficient evidence
- Vitamin K and SertralineInsufficient evidence
- Vitamin K and MetforminInsufficient evidence
- Vitamin K and MelatoninInsufficient evidence
- Vitamin K and AtorvastatinInsufficient evidence