Can I Take These?

Can You Take Spironolactone and Vitamin B12 Together?

No documented interaction was identified between spironolactone and vitamin B12 in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Spironolactone page and Vitamin B12 page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA label's Drug Interactions section does not mention vitamin B12. Vitamin B12's own NIH fact sheet does not mention spironolactone.

No documented interaction between Spironolactone and Vitamin B12 was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both Spironolactone's and Vitamin B12's own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Vitamin B12 — Consumer — NIH Office of Dietary SupplementsSpironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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