Can You Take St. John's Wort and Vitamin B12 Together?
No documented interaction was identified between St. John's Wort and vitamin B12 in the sources reviewed.
See the full St. John's Wort page and Vitamin B12 page for other reviewed interactions and reference information.
What the interaction means
NCCIH's St. John's Wort page names several drugs it can weaken (antidepressants, birth control, cyclosporine, anticonvulsants, heart medications, HIV drugs, cancer medications, warfarin, certain statins) -- vitamin B12 is not among them. Vitamin B12's own NIH fact sheet interactions section names only gastric acid inhibitors and metformin -- St. John's Wort is not among them either.
No documented interaction between St. John's Wort and Vitamin B12 was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
NCCIH's St. John's Wort page and vitamin B12's NIH ODS fact sheet were checked directly, full text, in both directions. Neither source names the other.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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