Can You Take St. John's Wort and Vitamin B12 Together?
No documented interaction was identified between St. John's Wort and vitamin B12 in the sources reviewed.
What the interaction means
NCCIH's St. John's Wort page does not mention vitamin B12. Vitamin B12's own NIH fact sheet does not mention St. John's Wort.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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