Can You Take Caffeine and St. John's Wort Together?
No documented interaction was identified between St. John's Wort and caffeine in the sources reviewed.
See the full Caffeine page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
NCCIH's St. John's Wort page names several drugs it can weaken (antidepressants, birth control, cyclosporine, anticonvulsants, heart medications, HIV drugs, cancer medications, warfarin, certain statins) -- caffeine is not among them. MedlinePlus's caffeine page does not mention St. John's Wort.
No documented interaction between Caffeine and St. John's Wort was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
NCCIH's St. John's Wort page and MedlinePlus's caffeine page were checked directly, full text, in both directions. Caffeine is not among St. John's Wort's named CYP450/P-glycoprotein-affected drugs.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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