Can I Take These?

Can You Take Caffeine and Omeprazole Together?

No documented interaction was identified between caffeine and omeprazole in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Caffeine page and Omeprazole page for other reviewed interactions and reference information.

What the interaction means

Omeprazole's FDA label does not mention caffeine anywhere, including its taxonomy dropdown. Caffeine's own MedlinePlus page does not mention omeprazole or acid-reducing medicines.

No documented interaction between Caffeine and Omeprazole was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Omeprazole's FDA label and caffeine's MedlinePlus page were checked directly, full text, in both directions. Neither page raises a caution about combining them.

What the sources say

Omeprazole Delayed-Release Capsules — FDA Prescribing Information — American Health Packaging (via DailyMed, U.S. National Library of Medicine)Caffeine — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related interactions