Can I Take These?

Can You Take Levothyroxine and Omeprazole Together?

Omeprazole, as a proton pump inhibitor, may reduce levothyroxine absorption -- named on levothyroxine's own FDA label at the drug-class level.

MonitorEvidence: Moderate

What the interaction means

Levothyroxine's FDA prescribing information states: "Gastric acidity is an essential requirement for adequate absorption of levothyroxine. Sucralfate, antacids and proton pump inhibitors may cause hypochlorhydria, affect intragastric pH, and reduce levothyroxine absorption. Monitor patients appropriately." Omeprazole is a proton pump inhibitor. Omeprazole's own FDA label does not separately name levothyroxine.

Why it may happen

Reduced gastric acidity from proton pump inhibitors impairs levothyroxine absorption, per the label.

Practical context

This is a proton-pump-inhibitor-class finding, not an omeprazole-specific subsection -- the label does not give a specific spacing interval or dose adjustment for this group (unlike its separate calcium carbonate/ferrous sulfate 4-hour instruction). The label's guidance is to monitor thyroid function, not to avoid the combination.

What the sources say

Omeprazole Delayed-Release Capsules — FDA Prescribing Information — American Health Packaging (via DailyMed, U.S. National Library of Medicine)Levothyroxine Sodium Capsules — FDA Prescribing Information — YARAL Pharma, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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