Can I Take These?

Can You Take Caffeine and Levothyroxine Together?

No documented interaction was identified between levothyroxine and caffeine in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Caffeine page and Levothyroxine page for other reviewed interactions and reference information.

What the interaction means

Levothyroxine's extensive drug-interaction section (absorption, protein-transport, and metabolism effects) does not name caffeine. MedlinePlus's caffeine page does not mention levothyroxine or thyroid medications.

No documented interaction between Caffeine and Levothyroxine was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Levothyroxine's FDA label and caffeine's MedlinePlus page were checked directly, full text, in both directions. Levothyroxine's label documents specific substances that reduce its absorption (calcium carbonate, ferrous sulfate, PPIs/sucralfate/antacids) but does not name coffee or caffeine among them.

What the sources say

Levothyroxine Sodium Capsules — FDA Prescribing Information — YARAL Pharma, Inc. (via DailyMed, U.S. National Library of Medicine)Caffeine — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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