Can I Take These?

Can You Take Doxycycline and Levothyroxine Together?

No documented interaction was identified between levothyroxine and doxycycline in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Doxycycline page and Levothyroxine page for other reviewed interactions and reference information.

What the interaction means

Levothyroxine's extensive drug-interaction section (absorption, protein-transport, and metabolism effects) does not name doxycycline. Doxycycline's own FDA label does not mention levothyroxine.

No documented interaction between Doxycycline and Levothyroxine was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Levothyroxine's and doxycycline's FDA labels were checked directly, full text, in both directions. Neither drug is named in the other's drug-interaction section.

What the sources say

Doxycycline Hyclate — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Levothyroxine Sodium Capsules — FDA Prescribing Information — YARAL Pharma, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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