Doxycycline
A prescription tetracycline-class antibiotic used to treat a wide range of bacterial infections.
What it is
Doxycycline is a tetracycline-class antibiotic used to treat many types of bacterial infections, including rickettsial diseases (such as Rocky Mountain spotted fever), respiratory infections, sexually transmitted infections, and various other gram-negative and gram-positive infections. It's also used for malaria prophylaxis and as post-exposure treatment for anthrax.
Food and timing considerations
The FDA label states that doxycycline's absorption is not markedly influenced by simultaneous ingestion of food or milk -- unlike some other tetracyclines, which are more food/dairy-sensitive. This is separate from its documented interaction with calcium, magnesium, and iron supplements/antacids (see interaction pages).
Known interaction categories
- Use caution
- Informational
- Insufficient evidence
Published interaction pages on this site
- Doxycycline and IronUse caution
- Doxycycline and ProbioticsInformational
- Doxycycline and MagnesiumUse caution
- Doxycycline and CalciumUse caution
- Doxycycline and WarfarinInsufficient evidence
- Doxycycline and Vitamin B12Insufficient evidence
- Doxycycline and PotassiumInsufficient evidence
- Doxycycline and St. John's WortInsufficient evidence
- Doxycycline and AtorvastatinInsufficient evidence
- Doxycycline and MetforminInsufficient evidence
- Doxycycline and Vitamin DInsufficient evidence
- Doxycycline and LisinoprilInsufficient evidence
- Doxycycline and CoQ10 (Coenzyme Q10)Insufficient evidence
- Doxycycline and OmeprazoleInsufficient evidence
- Doxycycline and SertralineInsufficient evidence
- Doxycycline and MelatoninInsufficient evidence
- Doxycycline and Vitamin KInsufficient evidence
- Doxycycline and LevothyroxineInsufficient evidence
- Doxycycline and CreatineInsufficient evidence
- Doxycycline and CopperInsufficient evidence
- Doxycycline and SpironolactoneInsufficient evidence
- Doxycycline and ZincUse caution
- Doxycycline and CaffeineInsufficient evidence
- Doxycycline and TurmericInsufficient evidence
Sources
Last reviewed 2026-08-22
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.