Can You Take Doxycycline and St. John's Wort Together?
No documented interaction was identified between doxycycline and St. John's Wort in the sources reviewed.
See the full Doxycycline page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
Doxycycline's FDA label does not mention St. John's Wort. NCCIH's St. John's Wort page names several drugs it can weaken (antidepressants, birth control, cyclosporine, anticonvulsants, heart medications, HIV drugs, cancer medications, warfarin, certain statins) -- doxycycline or antibiotics generally are not among them.
No documented interaction between Doxycycline and St. John's Wort was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Doxycycline's FDA label and NCCIH's St. John's Wort page were checked directly, full text, in both directions. Neither source names the other.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
Related guides
Related interactions
- Doxycycline and IronUse caution
- Doxycycline and ProbioticsInformational
- Doxycycline and MagnesiumUse caution
- Doxycycline and CalciumUse caution
- Doxycycline and CiprofloxacinInsufficient evidence
- Doxycycline and WarfarinInsufficient evidence
- Doxycycline and Vitamin B12Insufficient evidence
- Doxycycline and PotassiumInsufficient evidence
- Doxycycline and AtorvastatinInsufficient evidence
- Doxycycline and MetforminInsufficient evidence
- Doxycycline and Vitamin DInsufficient evidence
- Doxycycline and CoQ10 (Coenzyme Q10)Insufficient evidence
- Doxycycline and OmeprazoleInsufficient evidence
- Doxycycline and SertralineInsufficient evidence
- Doxycycline and MelatoninInsufficient evidence
- Doxycycline and Vitamin KInsufficient evidence
- Doxycycline and CreatineInsufficient evidence
- Doxycycline and CopperInsufficient evidence
- Doxycycline and SpironolactoneInsufficient evidence
- Doxycycline and ZincUse caution
- Doxycycline and CaffeineInsufficient evidence
- Doxycycline and Omega-3 / Fish OilInsufficient evidence
- Doxycycline and Vitamin EInsufficient evidence
- Doxycycline and Vitamin CInsufficient evidence
- Doxycycline and Folate / Folic AcidInsufficient evidence
- Doxycycline and AshwagandhaInsufficient evidence
- Doxycycline and LisinoprilInsufficient evidence
- Doxycycline and LosartanInsufficient evidence
- Doxycycline and AmlodipineInsufficient evidence
- Doxycycline and AspirinInsufficient evidence
- Doxycycline and LevothyroxineInsufficient evidence
- Doxycycline and IbuprofenInsufficient evidence
- Doxycycline and EscitalopramInsufficient evidence
- Doxycycline and TurmericInsufficient evidence
- St. John's Wort and CiprofloxacinInsufficient evidence
- St. John's Wort and WarfarinUse caution
- St. John's Wort and SertralineUse caution
- St. John's Wort and Vitamin EInsufficient evidence
- St. John's Wort and Vitamin KInsufficient evidence
- St. John's Wort and PotassiumInsufficient evidence
- St. John's Wort and SpironolactoneInsufficient evidence
- St. John's Wort and OmeprazoleInsufficient evidence
- St. John's Wort and MetforminInsufficient evidence
- St. John's Wort and CopperInsufficient evidence
- St. John's Wort and CaffeineInsufficient evidence
- St. John's Wort and Vitamin DInsufficient evidence
- St. John's Wort and CreatineInsufficient evidence
- St. John's Wort and Vitamin CInsufficient evidence
- St. John's Wort and CalciumInsufficient evidence
- St. John's Wort and IronInsufficient evidence
- St. John's Wort and MagnesiumInsufficient evidence
- St. John's Wort and Vitamin B12Insufficient evidence
- St. John's Wort and AshwagandhaInsufficient evidence
- St. John's Wort and Omega-3 / Fish OilInsufficient evidence
- St. John's Wort and ZincInsufficient evidence
- St. John's Wort and LisinoprilInsufficient evidence
- St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
- St. John's Wort and Folate / Folic AcidInsufficient evidence
- St. John's Wort and AtorvastatinMonitor
- St. John's Wort and LosartanInsufficient evidence
- St. John's Wort and MelatoninInsufficient evidence
- St. John's Wort and ProbioticsInsufficient evidence
- St. John's Wort and AspirinInsufficient evidence
- St. John's Wort and AmlodipineInsufficient evidence
- St. John's Wort and LevothyroxineInsufficient evidence
- St. John's Wort and IbuprofenInsufficient evidence
- St. John's Wort and TurmericInsufficient evidence
- St. John's Wort and EscitalopramUse caution