Can You Take Doxycycline and St. John's Wort Together?
No documented interaction was identified between doxycycline and St. John's Wort in the sources reviewed.
What the interaction means
Doxycycline's FDA label does not mention St. John's Wort. NCCIH's St. John's Wort page does not mention doxycycline.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- St. John's Wort and SertralineUse caution
- St. John's Wort and Vitamin B12Insufficient evidence
- St. John's Wort and Vitamin KInsufficient evidence
- St. John's Wort and LevothyroxineInsufficient evidence
- St. John's Wort and PotassiumInsufficient evidence
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- St. John's Wort and AtorvastatinInsufficient evidence
- St. John's Wort and ZincInsufficient evidence
- St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
- St. John's Wort and OmeprazoleInsufficient evidence
- St. John's Wort and MetforminInsufficient evidence
- St. John's Wort and LisinoprilInsufficient evidence
- St. John's Wort and CopperInsufficient evidence
- St. John's Wort and CaffeineInsufficient evidence
- St. John's Wort and Vitamin DInsufficient evidence
- St. John's Wort and ProbioticsInsufficient evidence
- St. John's Wort and CreatineInsufficient evidence
- St. John's Wort and MelatoninInsufficient evidence
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