Can You Take St. John's Wort and Zinc Together?
No documented interaction was identified between St. John's Wort and zinc in the sources reviewed.
See the full St. John's Wort page and Zinc page for other reviewed interactions and reference information.
What the interaction means
NCCIH's St. John's Wort page names several drugs it can weaken (antidepressants, birth control, cyclosporine, anticonvulsants, heart medications, HIV drugs, cancer medications, warfarin, certain statins) -- zinc is not among them. Zinc's own NIH fact sheet interactions section names only quinolone antibiotics, tetracycline antibiotics, penicillamine, and thiazide diuretics -- St. John's Wort is not among them either.
No documented interaction between St. John's Wort and Zinc was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
NCCIH's St. John's Wort page and zinc's NIH ODS fact sheet were checked directly, full text, in both directions. Neither source names the other.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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