Can You Take Losartan and St. John's Wort Together?
No documented interaction was identified between losartan and St. John's Wort in the sources reviewed.
See the full Losartan page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
Losartan's FDA label does not mention St. John's Wort. NCCIH's St. John's Wort fact sheet does not mention losartan, ARBs, angiotensin, or blood pressure medications; its named drug interactions are antidepressants, birth control pills, cyclosporine, anticonvulsants, digoxin, ivabradine, certain antiretrovirals, certain cancer drugs, warfarin, and simvastatin.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
St. John's Wort is a well-known CYP3A4/P-glycoprotein inducer, and losartan's own label documents that the CYP3A4 inducer rifampin reduces losartan's blood levels -- a plausible shared mechanism was checked directly, but St. John's Wort's own current fact sheet does not name losartan, ARBs, or blood pressure medications as a class, so no interaction is documented in the sources reviewed.
What the sources say
Last reviewed 2026-08-24
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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