Can I Take These?

Can You Take Losartan and Omeprazole Together?

No documented interaction was identified between losartan and omeprazole in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Losartan page and Omeprazole page for other reviewed interactions and reference information.

What the interaction means

Losartan's FDA label documents four drug-interaction categories -- potassium-raising drugs, lithium, NSAIDs, and dual RAS blockade with other ARBs/ACE inhibitors -- and omeprazole or proton pump inhibitors are not among them. Omeprazole's own FDA label does not mention losartan, ARBs, or angiotensin.

No documented interaction between Losartan and Omeprazole was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Losartan's FDA label and omeprazole's FDA label were checked directly, full text, in both directions. Losartan's own named interaction categories do not include proton pump inhibitors or other acid-reducing medicines.

What the sources say

Omeprazole Delayed-Release Capsules — FDA Prescribing Information — American Health Packaging (via DailyMed, U.S. National Library of Medicine)Losartan Potassium Tablets — FDA Prescribing Information — Bryant Ranch Prepack (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related guides

Related interactions