Can You Take Iron and Omeprazole Together?
Omeprazole can reduce iron absorption -- named directly on its FDA label as a drug dependent on gastric pH.
See the full Iron page and Omeprazole page for other reviewed interactions and reference information.
What the interaction means
Omeprazole's FDA prescribing information lists iron salts, under "Drugs Dependent on Gastric pH for Absorption," stating: "Omeprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity." The NIH ODS iron fact sheet corroborates this from the iron side, noting that proton pump inhibitors (including omeprazole) can reduce iron absorption by lowering stomach acid.
Why it may happen
Reduced intragastric acidity from omeprazole is described as lowering the absorption of drugs and nutrients, including iron, that depend on an acidic stomach environment for absorption.
Practical context
Most relevant for people on long-term omeprazole therapy; the label does not give a specific spacing interval or dose intervention for iron the way it does for some other interacting drugs. Anyone relying on iron supplementation while on long-term PPI therapy should discuss monitoring with their prescriber.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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