Can I Take These?

Can You Take Calcium and Omeprazole Together?

Long-term, high-dose omeprazole use is associated with an increased risk of bone fracture -- its FDA label documents this directly.

MonitorEvidence: High

See the full Calcium page and Omeprazole page for other reviewed interactions and reference information.

What the interaction means

Omeprazole's FDA prescribing information states: "The risk of fracture was increased in patients who received high-dose, defined as multiple daily doses, and long-term PPI therapy (a year or longer)." The label recommends: "Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated."

Why it may happen

The label does not use the phrase "calcium absorption" explicitly -- this is documented as a fracture-risk finding tied to high-dose, long-term acid suppression, not stated as a direct calcium-level or calcium-absorption claim. Framed here accordingly, rather than as a more specific mechanism than the label supports.

Practical context

The finding applies to high-dose (multiple daily doses) and long-term (a year or longer) use -- not typical short-course or once-daily use. No spacing interval applies; this is a duration/dose consideration, not a same-day timing issue.

What the sources say

Omeprazole Delayed-Release Capsules — FDA Prescribing Information — American Health Packaging (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-22

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related guides

Related interactions