Can I Take These?

Can You Take Omeprazole and Sertraline Together?

No documented interaction was identified between omeprazole and sertraline in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Omeprazole page and Sertraline page for other reviewed interactions and reference information.

What the interaction means

Neither omeprazole's nor sertraline's FDA label mentions the other substance anywhere.

No documented interaction between Omeprazole and Sertraline was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both Omeprazole's and Sertraline's own current FDA labels were checked directly, full text, in both directions.

What the sources say

Omeprazole Delayed-Release Capsules — FDA Prescribing Information — American Health Packaging (via DailyMed, U.S. National Library of Medicine)Sertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of Medicine

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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