Can You Take Omeprazole and St. John's Wort Together?
No documented interaction was identified between omeprazole and St. John's Wort in the sources reviewed.
See the full Omeprazole page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
Omeprazole's FDA label does not mention St. John's Wort. NCCIH's St. John's Wort page names several drugs it can weaken (antidepressants, birth control, cyclosporine, anticonvulsants, heart medications, HIV drugs, cancer medications, warfarin, certain statins) -- omeprazole or proton pump inhibitors are not among them.
No documented interaction between Omeprazole and St. John's Wort was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Omeprazole's FDA label and NCCIH's St. John's Wort page were checked directly, full text, in both directions. Neither source names the other.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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