Can You Take St. John's Wort and Vitamin D Together?
No documented interaction was identified between St. John's Wort and vitamin D in the sources reviewed.
What the interaction means
NCCIH's St. John's Wort page mentions "vitamin D" only as an example within a generic reference to NIH ODS's catalog of unrelated fact sheet topics, not an interaction claim. MedlinePlus's vitamin D page does not mention St. John's Wort.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked; the generic catalog-reference mention was deliberately not treated as a real interaction claim.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- St. John's Wort and IronInsufficient evidence
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- St. John's Wort and Vitamin B12Insufficient evidence
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- St. John's Wort and LevothyroxineInsufficient evidence
- St. John's Wort and PotassiumInsufficient evidence
- St. John's Wort and SpironolactoneInsufficient evidence
- St. John's Wort and AtorvastatinInsufficient evidence
- St. John's Wort and ZincInsufficient evidence
- St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
- St. John's Wort and OmeprazoleInsufficient evidence
- St. John's Wort and MetforminInsufficient evidence
- St. John's Wort and LisinoprilInsufficient evidence
- St. John's Wort and DoxycyclineInsufficient evidence
- St. John's Wort and CopperInsufficient evidence
- St. John's Wort and CaffeineInsufficient evidence
- St. John's Wort and ProbioticsInsufficient evidence
- St. John's Wort and CreatineInsufficient evidence
- St. John's Wort and MelatoninInsufficient evidence
- St. John's Wort and TurmericInsufficient evidence
- Vitamin D and CalciumInformational
- Vitamin D and Vitamin KInsufficient evidence
- Vitamin D and IronInsufficient evidence
- Vitamin D and CiprofloxacinInsufficient evidence
- Vitamin D and LevothyroxineInsufficient evidence
- Vitamin D and MagnesiumInsufficient evidence
- Vitamin D and WarfarinInsufficient evidence
- Vitamin D and CoQ10 (Coenzyme Q10)Insufficient evidence
- Vitamin D and Vitamin B12Insufficient evidence
- Vitamin D and PotassiumInsufficient evidence
- Vitamin D and DoxycyclineInsufficient evidence
- Vitamin D and CopperInsufficient evidence
- Vitamin D and TurmericInsufficient evidence
- Vitamin D and LisinoprilInsufficient evidence
- Vitamin D and ZincInsufficient evidence
- Vitamin D and SpironolactoneInsufficient evidence
- Vitamin D and MetforminInsufficient evidence
- Vitamin D and ProbioticsInsufficient evidence
- Vitamin D and MelatoninInsufficient evidence
- Vitamin D and OmeprazoleInsufficient evidence
- Vitamin D and SertralineInsufficient evidence
- Vitamin D and AtorvastatinInsufficient evidence
- Vitamin D and CaffeineInsufficient evidence
- Vitamin D and CreatineInsufficient evidence