St. John's Wort

What it is

St. John's Wort (Hypericum perforatum) is an herbal supplement sold over the counter in the United States; it has no FDA drug approval. It has been studied and used, particularly in Europe, for depression-related symptoms. It is one of the most well-documented herb-drug interaction sources: NCCIH states that St. John's wort "can interact in dangerous, sometimes life-threatening ways with a variety of medicines" through inducing cytochrome P-450 liver enzymes and intestinal P-glycoprotein, which can speed up how quickly the body clears many other medications.

Known interaction categories

• Insufficient evidence
• Use caution

Published interaction pages on this site

• St. John's Wort and CiprofloxacinInsufficient evidence
• St. John's Wort and MagnesiumInsufficient evidence
• St. John's Wort and WarfarinUse caution
• St. John's Wort and CalciumInsufficient evidence
• St. John's Wort and IronInsufficient evidence
• St. John's Wort and SertralineUse caution
• St. John's Wort and Vitamin B12Insufficient evidence
• St. John's Wort and Vitamin KInsufficient evidence
• St. John's Wort and LevothyroxineInsufficient evidence
• St. John's Wort and PotassiumInsufficient evidence
• St. John's Wort and SpironolactoneInsufficient evidence
• St. John's Wort and AtorvastatinInsufficient evidence
• St. John's Wort and ZincInsufficient evidence
• St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
• St. John's Wort and OmeprazoleInsufficient evidence
• St. John's Wort and MetforminInsufficient evidence
• St. John's Wort and LisinoprilInsufficient evidence
• St. John's Wort and DoxycyclineInsufficient evidence
• St. John's Wort and CopperInsufficient evidence
• St. John's Wort and CaffeineInsufficient evidence
• St. John's Wort and Vitamin DInsufficient evidence
• St. John's Wort and ProbioticsInsufficient evidence
• St. John's Wort and CreatineInsufficient evidence
• St. John's Wort and MelatoninInsufficient evidence
• St. John's Wort and TurmericInsufficient evidence

Sources