Can I Take These?

Can You Take Ibuprofen and Omeprazole Together?

No documented interaction was identified between ibuprofen and omeprazole in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Ibuprofen page and Omeprazole page for other reviewed interactions and reference information.

What the interaction means

Ibuprofen's own FDA label does not name omeprazole anywhere in its Drug Interactions section. Omeprazole's own FDA label does not mention ibuprofen, aspirin, NSAID, or salicylate anywhere.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions. Note that PPIs like omeprazole are sometimes recommended clinically alongside NSAIDs like ibuprofen to reduce gastrointestinal bleeding risk, but this specific combination is not described in either FDA label reviewed.

What the sources say

Omeprazole Delayed-Release Capsules — FDA Prescribing Information — American Health Packaging (via DailyMed, U.S. National Library of Medicine)Ibuprofen Tablets, USP — FDA Prescribing Information — Ascend Laboratories, LLC (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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